KRAS p.G13C Reference Standard
CBP10299#
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產(chǎn)品描述
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| Introduction | |
| Format | Genomic DNA |
| Description | KRAS G13C is a hotspot mutation that lies within a GTP binding region of the Kras protein (UniProt.org). G13C results in decreased Kras GTPase activity, as indicated by increased Ras-GTP, and leads to activation of downstream signaling in cell culture (PMID: 25705018, PMID: 21079152). |
| Technical Data | |
| DNA Change | c.37G>T |
| AA Change | p.G13C |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 50.00% |
| Transcript | ENST00000311936 |
| Cosmic ID | COSM527 |
| Chr position(GRCh37) | chr12:25398282 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
