ACVR2B Effector Reporter Cell
CBP74280
詢 價
索取Protocol
產品描述
產品數據庫
| I. Background | |
|
激活素 A（Activin A）是轉化生長因子-β（TGF-β）超家族的重要成員，是一種多能因 子，參與過敏、自身免疫性疾病、癌癥等免疫失調疾病的發(fā)生。 |
|
| II. Description | |
|
ACVR2B Effector Reporter Cell 報告基因藥靶模型很好的模擬了體內 ACVR2A 的信號轉導過程，原理見圖 所示。
|
|
| III. Introduction | |
| Expressed gene: | ACVR2B |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+ 200 μg/ml Hygromycin B |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
IV. Representative Data Figure 2. ACVR2B Effector Reporter Cell 測序結果 ACVR2A(NM_001616.5): c.409_410insT/ ACVR2A:p.Y137Lfs*76  Figure 3. Dose Response of Recombinant Human Activin A in ACVR2B Effector Cell(2C8).Dose Response of Recombinant Human GDF-8 in ACVR2B Effector Reporter Cell(2C8).Dose Response of Recombinant Human GDF-11 in ACVR2B Effector Reporter Cell (2C8). |
|
Figure 4. Inhibition ofHuman GDF-8 induced Reporter Activity byACVR2 Blocking Ab in ACVR2B Effector Reporter Cell(2C8). Inhibition of Human GDF-11 induced Reporter Activity by ACVR2 Blocking Ab in ACVR2B Effector Reporter Cell(2C8).
Figure 5. Inhibition of Recombinant Human Activin A-induced Reporter Activity by Samples in ACVR2B Effector Reporter Cell (2C8).
