ACE2 over-expression/A549 cell line
CBPC0003
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| I. Background | |
| Human Angiotensin converting enzyme 2 (ACE2), also known as ACEH, is an integral membrane protein found on the surface of cells in the lungs, arteries, heart, kidney, and intestines. | |
| II. Description | |
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ACE2 serves as the entry point into cells for some coronaviruses, including the two strains that caused outbreaks of Severe acute respiratory syndrome (SARS-CoV) and coronavirus disease 2019 (COVID-19) (SARS-CoV-2). |
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| III. Introduction | |
| Host Cell: | A549 |
| Expressed gene: | ACE2 |
| Stability: | 32 passages(in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | Angiotensin converting enzyme 2, ACEH, SARS-CoV, Coronavirus, COVID-19, SARS-CoV-2, ACE2 cells, ACE2 cell assay, covid19 |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: |
F12K+10%FBS+2ug/ml puromycin |
| Application(s): | Antibody Neutralizing Assay with 2019-nCov-S Pseudovirus |
| Storage: | Liquid nitrogen |
| IV. Description of Host Cell Line | |
| Organism: | Homo sapiens, human |
| Tissue: | Lung |
| Disease: | Carcinoma |
| Morphology: | Epithelial cells, growing adherently as monolayer |
| Growth Properties: | Adherent |
| Ⅴ. Representative Data | |
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Figure 1. Recombinant A549 cell constitutively expressing full length human ACE2. |
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